Long-term regulation of renal urea transporter protein expression in rat.

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Long-term regulation of renal urea transporter protein expression in rat.

To test the hypothesis that the abundance of the apical urea transporter of the inner medullary collecting duct (IMCD) is regulated in vivo by factors associated with altered water balance, immunoblots of rat inner medullary membrane fractions were probed with rabbit polyclonal antibodies against the renal urea transporter (RUT) gene product. In inner medullas of Brattleboro rats, which manifes...

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Long-term regulation of urea transporter expression by vasopressin in Brattleboro rats.

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Long-Term Regulation of Renal Urea Transporters during Antidiuresis

To produce a concentrated urine, the renal medulla needs hypertonicity for the reabsorption of free water from collecting duct. The single effect that increases interstitial tonicity in the outer medulla is the active NaCl reabsorption in the thick ascending limb, while the single effect in the inner medulla is the passive efflux of NaCl through the thin ascending limb. The passive mechanism in...

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Vasopressin regulation of the renal UT-A3 urea transporter.

Facilitative urea transporters in the mammalian kidney play a vital role in the urinary concentrating mechanism. The urea transporters located in the renal inner medullary collecting duct, namely UT-A1 and UT-A3, are acutely regulated by the antidiuretic hormone vasopressin. In this study, we investigated the vasopressin regulation of the basolateral urea transporter UT-A3 using an MDCK-mUT-A3 ...

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ژورنال

عنوان ژورنال: Journal of the American Society of Nephrology

سال: 1998

ISSN: 1046-6673,1533-3450

DOI: 10.1681/asn.v95729